Herb blend
SciatiEase Herbal Blend: Feverfew, Passionflower, Chinese Skullcap and Oat Straw in 50 mg
The SciatiEase herbal blend is a 50 mg proprietary mix of four 4:1 extracts: feverfew, passionflower, Chinese skullcap and oat straw. The label hides each amount, but the listing order caps them: at most 50, 25, 16.7 and 12.5 mg. None is proven for sciatica, and feverfew and skullcap need care with blood thinners.
Written by the SciatiEase label deskUpdated
The basics01
What is the SciatiEase herbal blend?
The SciatiEase herbal blend is a 50 mg proprietary blend of four plant extracts. It lists feverfew flower, passionflower, Chinese skullcap root and oat straw, each a 4:1 extract.
A 4:1 extract usually means about 4 parts of dried plant went into 1 part of finished extract. The label does not name the solvent.
The blend is the smallest part of the formula: 50 mg of herbs per serving, next to 500 mg of PEA.
None of the four has been tested for sciatica.
The math02
How much of each herb is in SciatiEase?
The exact amount of each herb is not printed. The rules let a proprietary blend show only its total weight, as long as the herbs are listed from most to least by weight (21 CFR 101.36 (eCFR)).
That order still gives a ceiling. The herb in place k can hold at most 50 divided by k milligrams, because every herb before it holds at least as much.
So feverfew, listed first, holds at most 50 mg. It also holds at least 12.5 mg, since the largest of four shares cannot be below a quarter of the total.
At 2 capsules, every ceiling halves.
| Place on label | Herb | Ceiling per 4 capsules | Ceiling per 2 capsules |
|---|---|---|---|
| 1 | Feverfew flower extract 4:1 | at most 50 mg | at most 25 mg |
| 2 | Passionflower extract 4:1 | at most 25 mg | at most 12.5 mg |
| 3 | Chinese skullcap root extract 4:1 | at most 16.7 mg | at most 8.3 mg |
| 4 | Oat straw extract 4:1 | at most 12.5 mg | at most 6.3 mg |
The whole panel, word for word, is on the supplement facts page.
The four herbs03
What is each herb in the blend known for?
Each herb is known for a traditional use, not for nerve pain. Feverfew is a headache herb. Passionflower and oat straw are calming herbs. Skullcap comes from Chinese medicine.
The research is thin. None of it used doses this small inside a nerve formula.
Feverfew
Studied for migraine with mixed results across 7 small studies (NCCIH, Feverfew). May slow clotting.
Passionflower
Small studies hint at less anxiety and longer sleep; nothing definite (NCCIH, Passionflower).
Chinese skullcap
Mostly lab and animal data; never tested alone in human trials (MSK, Scutellaria baicalensis).
Oat straw
Accepted in the EU on traditional use for mild stress and sleep (EMA, Oat herb (Avenae herba)).
| Name on the label | Feverfew (Tanacetum parthenium flower) extract 4:1 |
|---|---|
| What it is | Tanacetum parthenium, daisy-family herb |
| Group on the label | Herb blend, place 1 of 4 in the 50 mg blend |
| Amount per 4 capsules | Not listed; #1 of 4 in the 50 mg herb blend, so at most 50 mg per 4 capsules |
| Amount per 2 capsules | at most half of that |
| Amount used in research | Studied for migraine, not nerve pain |
| Strength of evidence | Not established for sciatica |
| Marketed or traditional use | Traditional headache herb |
| Main caution | May slow blood clotting; avoid in pregnancy. |
| Name on the label | Passionflower (Passiflora incarnata) extract 4:1 |
|---|---|
| What it is | Passiflora incarnata, vine |
| Group on the label | Herb blend, place 2 of 4 in the 50 mg blend |
| Amount per 4 capsules | Not listed; #2 of 4 in the 50 mg herb blend, so at most 25 mg per 4 capsules |
| Amount per 2 capsules | at most half of that |
| Amount used in research | Studied for anxiety and sleep |
| Strength of evidence | Not established for sciatica |
| Marketed or traditional use | Traditional calming herb |
| Main caution | Can cause drowsiness; take care with sedatives. |
| Name on the label | Chinese Skullcap (root) extract 4:1 |
|---|---|
| What it is | Scutellaria baicalensis root |
| Group on the label | Herb blend, place 3 of 4 in the 50 mg blend |
| Amount per 4 capsules | Not listed; #3 of 4 in the 50 mg herb blend, so at most 16.7 mg per 4 capsules |
| Amount per 2 capsules | at most half of that |
| Amount used in research | No sciatica dose established |
| Strength of evidence | Not established |
| Marketed or traditional use | Traditional Chinese herb |
| Main caution | Liver injury case reports; may add to warfarin (lab data). |
| Name on the label | Oat Straw (Avena sativa) extract 4:1 |
|---|---|
| What it is | Green oat plant tops |
| Group on the label | Herb blend, place 4 of 4 in the 50 mg blend |
| Amount per 4 capsules | Not listed; #4 of 4 in the 50 mg herb blend, so at most 12.5 mg per 4 capsules |
| Amount per 2 capsules | at most half of that |
| Amount used in research | No sciatica dose established |
| Strength of evidence | Not established |
| Marketed or traditional use | Traditional tonic |
| Main caution | Generally well tolerated; avoid with celiac disease unless certified gluten free. |
Safety04
Are the herbs in SciatiEase safe?
The herbs are small in amount, but two of them carry real cautions. Feverfew may slow blood clotting, and Chinese skullcap has case reports of liver injury (NCCIH, Feverfew) (MSK, Scutellaria baicalensis).
Lab studies suggest skullcap may add to the effect of warfarin and other blood thinners. It also lowered statin levels in healthy volunteers (MSK, Scutellaria baicalensis).
Passionflower can cause drowsiness or dizziness (NCCIH, Passionflower). Avoid feverfew and passionflower in pregnancy (NCCIH, Feverfew) (NCCIH, Passionflower).
People allergic to ragweed may react to feverfew (NCCIH, Feverfew). Tell every prescriber what you take (NCCIH, Herb-Drug Interactions).
take warfarin, apixaban or another blood thinner; take a statin, a sedative, gabapentin or pregabalin; have liver disease; are pregnant or nursing; or have surgery planned. Feverfew should be stopped at least 2 weeks before surgery (NCCIH, Feverfew).
Never stop or change a blood thinner or any other prescribed medicine because of a supplement. See the supplements and nerve medicines guide.

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See packsSciatica05
Can the herbal blend help sciatica?
No study shows that these four herbs help sciatica. Their research covers migraine, anxiety, sleep and stress.
Sciatica comes from pressure on a nerve root in the low back (MedlinePlus, Sciatica). Staying active is the usual first step, and most cases ease in 4 to 6 weeks (NHS, Sciatica).
Sciatica in both legs, numbness around the genitals or bottom, bladder or bowel changes, weak legs, or pain after an injury needs emergency care (AANS, Cauda Equina Syndrome). More on side effects and sciatica basics.
Other ingredients07
What else is in SciatiEase besides the herbs?
The other eight lines carry printed amounts: four B vitamins, PEA, R-alpha lipoic acid, acetyl-L-carnitine and benfotiamine.
FAQ08
Herbal blend questions
How much feverfew is in SciatiEase?
The label does not say. Feverfew is listed first in the 50 mg blend, so it holds at most 50 mg and at least 12.5 mg per 4 capsules (21 CFR 101.36 (eCFR)). At 2 capsules, halve those numbers. Ask the order desk if you need the exact figure.
Does feverfew interact with blood thinners?
It may. Feverfew may slow blood clotting, which could add to warfarin, apixaban or similar drugs (NCCIH, Feverfew). Chinese skullcap, also in the blend, may add to warfarin in lab studies (MSK, Scutellaria baicalensis). Ask your doctor before taking SciatiEase with any blood thinner.
Can the passionflower in SciatiEase cause drowsiness?
It might. Passionflower can cause drowsiness, dizziness and confusion (NCCIH, Passionflower). SciatiEase holds at most 25 mg per 4 capsules, a small amount, but the effect can add to sedatives, gabapentin or alcohol. See how you feel before driving.
Is Chinese skullcap bad for the liver?
There are case reports of liver injury from products with Chinese skullcap or its compound baicalin (MSK, Scutellaria baicalensis). A SciatiEase serving holds 16.7 mg of it at most. If you have liver disease, or notice dark urine or yellow skin, stop and call your doctor.
What does 4:1 extract mean on the SciatiEase label?
A 4:1 extract usually means about 4 parts of dried herb were used to make 1 part of extract. The SciatiEase panel lists all four herbs as 4:1 extracts. It does not name the solvent or the plant compounds kept.
Why does feverfew matter before surgery?
Ask your surgeon. Feverfew should be stopped at least 2 weeks before surgery because it may slow clotting (NCCIH, Feverfew), and passionflower may interact with anesthesia (NCCIH, Passionflower). Both are in the SciatiEase herbal blend.
Why does SciatiEase use a proprietary blend for its herbs?
Supplement rules allow a blend to show only its total weight, with herbs listed from most to least (21 CFR 101.36 (eCFR)). Makers often use blends to protect a recipe. The listing order still lets you work out the most each herb can hold.
Who wrote this09
Written and reviewed by
Pages built from the Supplement Facts panel, the brand pages and linked NIH, FDA, FTC, NHS and peer-reviewed sources.
Last updated . See our editorial standards and the way we check reviews. This website is run by Isciatiease, a U.S. desk for SciatiEase, not by the manufacturer or by SciatiEase Labs. Purchases made through our order links earn us a commission.
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