Ingredients
SciatiEase Ingredients: The Full List and Doses
SciatiEase is made from 12 ingredients per serving of 4 capsules, in gelatin capsule shells.
The main ones are PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg and benfotiamine 200 mg, plus B2, B6, folate, B12 and a 50 mg blend of feverfew, passionflower, Chinese skullcap and oat straw.
Next, read how SciatiEase works.
Written by the SciatiEase label deskUpdated
The full list01
What is in SciatiEase, line by line?
SciatiEase holds 12 ingredients on its Supplement Facts panel, grouped into four sets.
The largest four are PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg and benfotiamine 200 mg.
- 1Vitamin B2 (riboflavin-5-phosphate)25 mg per 4 capsules · 1,923% DV
- 2Vitamin B6 (pyridoxal-5-phosphate)20 mg per 4 capsules · 1,177% DV
- 3Folate (5-methyltetrahydrofolate)500 mcg DFE per 4 capsules · 120% DV
- 4Vitamin B12 (methylcobalamin)1 mg per 4 capsules · 41,667% DV
- 5R-Alpha Lipoic Acid (R-ALA)250 mg per 4 capsules
- 6Palmitoylethanolamide (PEA)500 mg per 4 capsules
- 7Acetyl-L-carnitine (ALCAR)250 mg per 4 capsules
- 8Benfotiamine200 mg per 4 capsules
- 9Feverfew (Tanacetum parthenium flower) extract 4:1Herb blend place 1 · at most 50 mg
- 10Passionflower (Passiflora incarnata) extract 4:1Herb blend place 2 · at most 25 mg
- 11Chinese Skullcap (root) extract 4:1Herb blend place 3 · at most 16.7 mg
- 12Oat Straw (Avena sativa) extract 4:1Herb blend place 4 · at most 12.5 mg
From the Supplement Facts panel. Eight lines print an amount; the four herbs share a 50 mg blend listed from most to least by weight (21 CFR 101.36 (eCFR)). Other ingredients (gelatin capsule, cellulose, vegetable stearate, silica) are not counted.
Profiles02
What does each SciatiEase ingredient group do?
Each SciatiEase ingredient group has a different role. Six profile pages cover all 12 lines.
Tap a card for doses, evidence and cautions.
-
500 mg01PEA (palmitoylethanolamide)
500 mg per 4 capsules, the largest line
A fatty acid amide the body also makes
Evidence: Small trials; some pain-score benefitA drawing made for this site, not a photo of the capsule contents.
Per 4 capsules500 mg per 4 capsules
Studied at300-600 mg a day in a 3-week sciatica trial
Watch forGenerally well tolerated in trials; long-term data are limited.
Full profile -
250 mg02R-alpha lipoic acid
250 mg per 4 capsules, R form
The R form of alpha-lipoic acid (antioxidant)
Evidence: Some symptom-score benefit in diabetic neuropathy; pain scores did not changeA drawing made for this site, not a photo of the capsule contents.
Per 4 capsules250 mg per 4 capsules
Studied at600-1,800 mg a day in oral neuropathy trials
Watch forMay lower blood sugar in people on diabetes medicine.
Full profile -
250 mg03Acetyl-L-carnitine
250 mg per 4 capsules
Acetylated form of carnitine
Evidence: Low-certainty; small pain effectA drawing made for this site, not a photo of the capsule contents.
Per 4 capsules250 mg per 4 capsules
Studied atUp to 3,000 mg a day in trials; 1,500 mg or less was no better than placebo
Watch forCan cause stomach upset and a fishy body odor.
Full profile -
200 mg04Benfotiamine
200 mg per 4 capsules
Fat-soluble form of vitamin B1 (thiamin)
Evidence: One short trial; one symptom score improvedA drawing made for this site, not a photo of the capsule contents.
Per 4 capsules200 mg per 4 capsules
Studied at300-600 mg a day in a 6-week diabetic neuropathy trial
Watch forGenerally well tolerated in trials.
Full profile -
4 label lines05The four B vitamins
B2, B6, folate and B12
Vitamin B2, Vitamin B6, Folate, Vitamin B12
Evidence: Helps when you are lowA drawing made for this site, not a photo of the capsule contents.
Per 4 capsulesB2 25 mg, B6 20 mg, folate 500 mcg, B12 1 mg
Studied atDoses vary; see the page
Watch forHigh doses over time can cause nerve damage. 20 mg is under the US 100 mg upper limit but above the EU limit of 12 mg.
Full profile -
4 label lines06The 50 mg herb blend
Four herbs sharing 50 mg
Feverfew, Passionflower, Chinese skullcap, Oat straw
Evidence: Not established for sciaticaA drawing made for this site. No herb photos came with the brand's images.
Per 4 capsules50 mg shared by four herbs
Studied atDoses vary; see the page
Watch forLiver injury case reports; may add to warfarin (lab data).
Full profile
Dose vs research03
How do SciatiEase ingredient doses compare with research?
Only PEA lands inside a studied range. Lipoic acid, acetyl-L-carnitine and benfotiamine sit below the doses most trials used.
Herb rows show upper bounds, not real amounts.
| Label line | Group | Per 4 capsules | Amount used in research | Evidence |
|---|---|---|---|---|
| Vitamin B2 (riboflavin-5-phosphate) | B vitamins | 25 mg 1,923% DV | 1.1-1.3 mg a day meets needs; 400 mg in migraine studies (NIH ODS, Riboflavin) | No nerve-pain trials |
| Vitamin B6 (pyridoxal-5-phosphate) | B vitamins | 20 mg 1,177% DV | 1.3-1.7 mg a day meets needs; upper limit 100 mg (NIH ODS, Vitamin B6) | Deficiency harms nerves; too much does too |
| Folate (5-methyltetrahydrofolate) | B vitamins | 500 mcg DFE 120% DV | 400 mcg DFE a day meets needs (NIH ODS, Folate) | No nerve-pain trials |
| Vitamin B12 (methylcobalamin) | B vitamins | 1 mg 41,667% DV | 2.4 mcg a day meets needs; 1,000 mcg used to correct low levels (NIH ODS, Vitamin B12) | Helps only if you are low |
| R-Alpha Lipoic Acid (R-ALA) | AlphaPalm blend | 250 mg | 600-1,800 mg a day in oral neuropathy trials (Linus Pauling Inst., Lipoic Acid) (Hsieh et al., Nutrients 2023) | Some symptom-score benefit in diabetic neuropathy; pain scores did not change |
| Palmitoylethanolamide (PEA) | AlphaPalm blend | 500 mg | 300-600 mg a day in a 3-week sciatica trial (Artukoglu et al., Pain Physician 2017) (Cruccu et al., CNS Drug Targets 2019) | Small trials; some pain-score benefit |
| Acetyl-L-carnitine (ALCAR) | Nerve nutrients | 250 mg | Up to 3,000 mg a day in trials; 1,500 mg or less was no better than placebo (NIH ODS, Carnitine) (Rolim et al., Cochrane 2019) | Low-certainty; small pain effect |
| Benfotiamine | Nerve nutrients | 200 mg | 300-600 mg a day in a 6-week diabetic neuropathy trial (NIH ODS, Thiamin) (Stracke et al., BENDIP 2008) | One short trial; one symptom score improved |
| Feverfew (Tanacetum parthenium flower) extract 4:1 | Herb blend | at most 50 mg | Studied for migraine, not nerve pain (NCCIH, Feverfew) | Not established for sciatica |
| Passionflower (Passiflora incarnata) extract 4:1 | Herb blend | at most 25 mg | Studied for anxiety and sleep (NCCIH, Passionflower) | Not established for sciatica |
| Chinese Skullcap (root) extract 4:1 | Herb blend | at most 16.7 mg | No sciatica dose established (MSK, Scutellaria baicalensis) | Not established |
| Oat Straw (Avena sativa) extract 4:1 | Herb blend | at most 12.5 mg | No sciatica dose established (EMA, Oat herb (Avenae herba)) | Not established |
Two sources04
Why do brand pages list larger SciatiEase ingredient amounts?
The brand's ingredients page prints larger amounts for four lines than the Supplement Facts panel does (SciatiEase ingredients page). We follow the panel.
The web page shows PEA 600 mg, R-ALA and ALCAR 300 mg each, and benfotiamine 300 mg. The panel shows 500, 250, 250 and 200 mg.
SciatiEase: from $49.99 a bottle120 capsules · 1, 3 or 6 bottles · 180-day money-back guarantee
See packsVitamin forms05
Which vitamin forms does SciatiEase use?
SciatiEase uses active vitamin forms: riboflavin-5-phosphate, pyridoxal-5-phosphate, 5-methyltetrahydrofolate and methylcobalamin.
The amounts run far past daily needs. B12 is 1 mg, but only about 1.3% of a 1,000 mcg oral dose is absorbed (NIH ODS, Vitamin B12).
Each serving has 20 mg of B6. That is under the US upper limit of 100 mg, but above the European limit of 12 mg set in 2023 (NIH ODS, Vitamin B6). Skip other B6 products while you take SciatiEase.
Full detail sits on the B vitamins page.
Other ingredients06
What is SciatiEase made of besides the actives?
Besides the 12 actives, SciatiEase contains gelatin, microcrystalline cellulose, vegetable stearate and silica. The gelatin forms the capsule shell, so the product is not vegetarian.
These fill the capsule and help the powder flow.
Herb blend07
How much of each herb is in SciatiEase?
The exact amount of each herb is not printed. The four herbs share a 50 mg proprietary blend, which the law allows (21 CFR 101.36 (eCFR)).
Herbs are listed from most to least by weight, so the herb in place k holds at most 50/k mg. Feverfew holds at most 50 mg, passionflower 25 mg, skullcap 16.7 mg and oat straw 12.5 mg. More on the herb blend page.
Feverfew may slow clotting (NCCIH, Feverfew), passionflower can cause drowsiness (NCCIH, Passionflower), skullcap has liver injury reports (MSK, Scutellaria baicalensis) and lipoic acid may lower blood sugar (Linus Pauling Inst., Lipoic Acid). On a blood thinner, gabapentin, a sleep aid or diabetes medicine, ask first. Keep taking prescribed medicine as directed. See side effects.
FAQ08
SciatiEase ingredients: common questions
What are the ingredients in SciatiEase?
SciatiEase lists 12 ingredients per 4 capsules: four B vitamins, PEA, R-alpha lipoic acid, acetyl-L-carnitine, benfotiamine and four herbs (feverfew, passionflower, Chinese skullcap, oat straw) in a 50 mg blend.
What are the active ingredients in SciatiEase?
The main actives are PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg and benfotiamine 200 mg per 4 capsules.
What is SciatiEase made of?
SciatiEase is made of 12 active lines inside a gelatin capsule, with microcrystalline cellulose, vegetable stearate and silica as other ingredients.
Does SciatiEase contain turmeric or magnesium?
No. Neither turmeric nor magnesium appears on the SciatiEase Supplement Facts panel.
Is the PEA in SciatiEase 500 mg or 600 mg?
The label says 500 mg of PEA per 4 capsules. The brand's ingredients page says 600 mg (SciatiEase ingredients page). We follow the label.
Why does SciatiEase use R-alpha lipoic acid instead of regular ALA?
The brand chose the R form, the one the body makes. Most trials used regular ALA at 600 mg or more a day (Hsieh et al., Nutrients 2023), so 250 mg of R-ALA has no direct trial behind it.
Who wrote this09
Written and reviewed by
Pages built from the Supplement Facts panel, the brand pages and linked NIH, FDA, FTC, NHS and peer-reviewed sources.
Last updated . See our editorial standards and the way we check reviews. This website is run by Isciatiease, a U.S. desk for SciatiEase, not by the manufacturer or by SciatiEase Labs. Purchases made through our order links earn us a commission.
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