Official website · U.S. desk for SciatiEase
"SciatiEase is a dietary supplement in capsules for sciatic nerve comfort."
Use case: For adults who want daily nerve comfort support: a serving is 4 capsules a day, taken with meals, from a 120-capsule bottle.
How it works: PEA 500 mg and benfotiamine 200 mg lead the formula, joined by R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg and a 50 mg herb blend.
Written by the SciatiEase label desk · Updated
SciatiEase Labs
SciatiEase
Supports Sciatic Nerve Health*
From $49.99 a bottle
Order SciatiEaseBrand photo of the real bottle. *Not evaluated by the FDA.
One serving, along the nerve path
Drawing, not dataThe sciatic nerve runs from the low back down the leg. The signals show what the label lists in one serving, grouped four ways, not what reaches the nerve or what it does there.
PEA check
12label lines
| Form | Capsules, white bottle of 120 |
|---|---|
| Serving | 4 capsules, 30 servings |
| Largest line | PEA 500 mg |
| Directions | 2 with breakfast, 2 with dinner |
| Brand | SciatiEase Labs, LLC, Smyrna, TN |
| Price | From $49.99 a bottle |
| Guarantee | 180 days, money back |
Claims vs evidence01
No result can be promised. SciatiEase is a dietary supplement for sciatic nerve comfort, and no trial has tested SciatiEase itself for sciatica or anything else.
Sciatica is pain that runs along the sciatic nerve, from the low back down the back of one leg. It usually starts when a disc or a narrowed spinal canal presses on a nerve root (MedlinePlus, Sciatica). A supplement cannot move a disc.
The ad-style sales page goes much further than the bottle does. It calls itself an advertisement in its own fine print (SciatiEase sales page), and its biggest lines have no source. Each claim below sits next to what the evidence shows.
Claims as printed on the sales page (SciatiEase sales page), the order page (SciatiEase order page), the about page (SciatiEase about page) and the bottle. Health claims need competent and reliable scientific evidence, generally human trials of the same product (FTC, Health Products Compliance).
Most sciatica gets better on its own within 4 to 6 weeks, and the first steps are staying active and simple pain relief (NHS, Sciatica). Read the fuller breakdown on the claims vs evidence page.
Do not stop, skip or cut gabapentin, a blood thinner or any other prescribed medicine because you started a supplement. Tell your care team before you begin.
How you take it02
Take SciatiEase as 2 capsules with breakfast and 2 more with dinner, which makes the full label serving of 4 capsules. One 120-capsule bottle holds 30 servings.
The Supplement Facts panel sets one serving at 4 capsules, with 30 servings in a bottle of 120. The sales page splits that into 2 capsules with breakfast and 2 with dinner (SciatiEase sales page). The brand's order page suggests the same for months 1 to 3, then 1 and 1 after that (SciatiEase order page).
Taking the capsules with food is the brand's advice, not a rule printed in the images we have. If you take only the morning pair, a bottle lasts 60 days instead of 30.
On a new bottle, check that the seal is intact and that the Supplement Facts panel matches: 4 capsules per serving, 30 servings.
The sales page starts with 2 capsules in the morning with food. Swallow them with water. That is half the label serving.
For the full 4-capsule serving on the label, add 2 with dinner. Do not go past the label serving without asking a doctor.
Note how you feel each week. The 180-day guarantee leaves room to judge it. Tell your doctor what you take.
Four capsules make one serving, so a single bottle is a 30-day supply at the label serving. The order page once suggested doubling to 4 capsules twice a day if results are slow (SciatiEase order page). That is twice the label serving, so ask your doctor before going past 4 a day. More detail sits on the how to take it page.
Ingredients03
SciatiEase lists twelve label lines: four B vitamins, PEA and R-alpha lipoic acid, acetyl-L-carnitine, benfotiamine and four herbs in a 50 mg blend, all listed on the Supplement Facts panel.
SciatiEase lists 12 ingredients on its Supplement Facts panel, which matches the "12 Research Backed Herbs, Vitamins & Antioxidants" line on the bottle front. Eight of them print an exact amount per 4 capsules. The four herbs share a 50 mg proprietary blend, so their single amounts stay hidden (21 CFR 101.36 (eCFR)).
The biggest line is palmitoylethanolamide (PEA) at 500 mg. It sits with R-alpha lipoic acid 250 mg inside what the label calls the AlphaPalm blend. The brand's own ingredients page prints larger amounts for four lines than the panel does (SciatiEase ingredients page); this site follows the panel.
From the Supplement Facts panel. Eight lines print an amount; the four herbs share a 50 mg blend listed from most to least by weight (21 CFR 101.36 (eCFR)). Other ingredients (gelatin capsule, cellulose, vegetable stearate, silica) are not counted.
500 mg500 mg per 4 capsules, the largest line
A fatty acid amide the body also makes
Evidence: Small trials; some pain-score benefitA drawing made for this site, not a photo of the capsule contents.
500 mg per 4 capsules
Studied at300-600 mg a day in a 3-week sciatica trial
Watch forGenerally well tolerated in trials; long-term data are limited.
Full profile
250 mg250 mg per 4 capsules, R form
The R form of alpha-lipoic acid (antioxidant)
Evidence: Some symptom-score benefit in diabetic neuropathy; pain scores did not changeA drawing made for this site, not a photo of the capsule contents.
250 mg per 4 capsules
Studied at600-1,800 mg a day in oral neuropathy trials
Watch forMay lower blood sugar in people on diabetes medicine.
Full profile
250 mg250 mg per 4 capsules
Acetylated form of carnitine
Evidence: Low-certainty; small pain effectA drawing made for this site, not a photo of the capsule contents.
250 mg per 4 capsules
Studied atUp to 3,000 mg a day in trials; 1,500 mg or less was no better than placebo
Watch forCan cause stomach upset and a fishy body odor.
Full profile
200 mg200 mg per 4 capsules
Fat-soluble form of vitamin B1 (thiamin)
Evidence: One short trial; one symptom score improvedA drawing made for this site, not a photo of the capsule contents.
200 mg per 4 capsules
Studied at300-600 mg a day in a 6-week diabetic neuropathy trial
Watch forGenerally well tolerated in trials.
Full profile
4 label linesB2, B6, folate and B12
Vitamin B2, Vitamin B6, Folate, Vitamin B12
Evidence: Helps when you are lowA drawing made for this site, not a photo of the capsule contents.
B2 25 mg, B6 20 mg, folate 500 mcg, B12 1 mg
Studied atDoses vary; see the page
Watch forHigh doses over time can cause nerve damage. 20 mg is under the US 100 mg upper limit but above the EU limit of 12 mg.
Full profile
4 label linesFour herbs sharing 50 mg
Feverfew, Passionflower, Chinese skullcap, Oat straw
Evidence: Not established for sciaticaA drawing made for this site. No herb photos came with the brand's images.
50 mg shared by four herbs
Studied atDoses vary; see the page
Watch forLiver injury case reports; may add to warfarin (lab data).
Full profileThe full panel, word for word, is on the supplement facts page.
The label04
The SciatiEase label has six numbered spots on its Supplement Facts panel. Tap any number to read that part in plain words, from the serving size to the herb blend.
The label is the most reliable record of what is in the bottle. It beats the ad, the brand's web pages and any review site. Where they disagree, we go with the panel and say so.
The images we have show the panel and the bottle front. They do not show the directions or warning text, so ask the order desk for a photo of those sides if you need them.
Tap a number to read that part of the panel.
4 capsules per serving, 30 servings per container: 120 capsules in all.
B2 25 mg (1,923% DV), B6 20 mg (1,177%), folate 500 mcg DFE (120%) and B12 1 mg (41,667%). B6 is under the US 100 mg upper limit, above the EU 12 mg limit.
A branded name for two printed lines: R-alpha lipoic acid 250 mg and PEA 500 mg.
Acetyl-L-carnitine 250 mg and benfotiamine 200 mg. Neuropathy trials used more of both.
Feverfew, passionflower, Chinese skullcap and oat straw, each a 4:1 extract. Single amounts are hidden; the order runs most to least.
Gelatin capsule, microcrystalline cellulose, vegetable stearate and silica. Gelatin means it is not vegetarian.
The front carries the claims. Each one has an asterisk, which points to the FDA statement: the claims have not been evaluated, and the product is not meant to treat any disease.
Tap a number to read that part of the bottle.
The blue band carries the brand name. The brand's website lists SciatiEase Labs, LLC in Smyrna, Tennessee.
A marketing line. Renders of the same bottle say 'Maximum Power'. Neither has a defined meaning.
The product name, with a registered-mark symbol.
A structure/function claim. The asterisk points to the FDA statement: not evaluated, not a treatment.
The panel does list 12 lines. 'Research backed' means the ingredients were studied, not this product.
Supports Comfort, Nerve Health and a Healthy Inflammatory Response, each with an asterisk.
Dose vs research05
In SciatiEase, PEA lands inside the studied range. R-alpha lipoic acid, acetyl-L-carnitine and benfotiamine sit below the doses most trials used, so the full 4-capsule serving matters.
PEA is the line that matches research best. A 3-week sciatica trial gave 300 or 600 mg a day (Cruccu et al., CNS Drug Targets 2019), and SciatiEase has 500 mg in 4 capsules. Take only 2 capsules and you get 250 mg.
The other nerve nutrients are lower. Oral lipoic acid trials used 600 to 1,800 mg a day (Hsieh et al., Nutrients 2023). In a Cochrane review, acetyl-L-carnitine at 1,500 mg a day or less did no better than placebo (Rolim et al., Cochrane 2019). Vitamin B6 is the reverse case: more is not better, so its bar shows the upper limit.
| Ingredient | Evidence | What it found |
|---|---|---|
| PEA | Meta-analysis (Artukoglu et al., Pain Physician 2017); sciatica trial (Cruccu et al., CNS Drug Targets 2019) | About a 2-point drop on a 10-point pain scale across small trials |
| Alpha lipoic acid | Meta-analysis of oral trials (Hsieh et al., Nutrients 2023) | Better symptom scores at higher doses; pain scores did not change |
| Acetyl-L-carnitine | Cochrane review (Rolim et al., Cochrane 2019) | Low-certainty evidence; low doses matched placebo |
| Benfotiamine | 6-week trial (Stracke et al., BENDIP 2008) | One symptom score improved in diabetic neuropathy |
Read each one in depth on the PEA page and the ingredients overview.
Bottle claims06
The SciatiEase bottle makes four support claims, each with an FDA asterisk. Each one is shown next to what studies of the single ingredients found, not what the product itself does.
A support claim describes how an ingredient may affect the body's normal workings. Supplements may use one if they carry the FDA statement and the seller has evidence (FTC, Health Products Compliance).
None of these claims names a disease, and none promises a result. That is the line between a supplement and a medicine.
The bottle says“Supports Sciatic Nerve Health*”
What the evidence saysNo trial has tested the product. B12, B1 (benfotiamine) and B6 matter for nerves mainly when you are short of them; extra helps little if your levels are normal. (NIH ODS, Vitamin B12) (NIH ODS, Thiamin) (NIH ODS, Vitamin B6)
The bottle says“Supports Daily Comfort*”
What the evidence saysPEA has small pain trials. In a 3-week sciatica trial, 300-600 mg a day lowered pain scores; the label serving has 500 mg. Studies were small and some had industry ties. (Artukoglu et al., Pain Physician 2017) (Cruccu et al., CNS Drug Targets 2019)
The bottle says“Supports Nerve Health*”
What the evidence saysLipoic acid and acetyl-L-carnitine showed small symptom changes in diabetic neuropathy, at 600 mg or more of ALA and over 1,500 mg of ALCAR. This serving has 250 mg of each. (Hsieh et al., Nutrients 2023) (Rolim et al., Cochrane 2019)
The bottle says“Supports Healthy Inflammatory Response*”
What the evidence saysPEA and feverfew are studied for inflammation pathways, but 'inflammatory response' is too broad to test. The herb blend shares only 50 mg. (Artukoglu et al., Pain Physician 2017) (NCCIH, Feverfew)
Icons drawn for this site. Claims as printed on the bottle and renders; the asterisk points to the FDA statement (FDA 101: Dietary Supplements).
Safety07
Ask a doctor first if you take a blood thinner, gabapentin or another sedating medicine, or if you are pregnant, nursing or under 18. No trial has tested SciatiEase itself.
SciatiEase is a mix of vitamins, nutrients and herbs, and a few of them can interact with medicines. Feverfew may slow blood clotting (NCCIH, Feverfew). Passionflower can make you drowsy (NCCIH, Passionflower). Lipoic acid may lower blood sugar (Linus Pauling Inst., Lipoic Acid).
Five questions sort out who should talk to a doctor first. A yes does not mean you can never take it; it means the conversation comes first.
Each serving has 20 mg of B6. That is under the US upper limit of 100 mg, but above the European limit of 12 mg, and long-term high B6 intake can cause nerve damage (NIH ODS, Vitamin B6). Do not stack it with another B6 product. More on side effects and interactions.
Know the nerve08
Sciatica most often comes from a pinched nerve root in the low back, felt along the sciatic nerve down one leg. It is a symptom, so a doctor should look for the cause.
The sciatic nerve forms from roots that leave the lower spine and runs through the buttock and down the back of the leg (MedlinePlus, Sciatica). Pressure on one of those roots, often from a bulging disc, causes the pain, tingling or numbness of sciatica.
Disc changes are common even without pain: one review found disc bulges in 30% of pain-free 20-year-olds and 84% of pain-free 80-year-olds (Brinjikji et al., AJNR 2015). A scan alone does not explain symptoms.
Nerve roots L4 to S3 leave the spine. The usual cause is a bulging disc or a narrowed space at this level.
The roots join into the sciatic nerve, the thickest nerve in the body.
Pain, tingling or numbness can run along this path, usually on one side.
The nerve splits; symptoms can reach the calf, foot and toes.
A drawing, not an anatomy chart. Sources: MedlinePlus (MedlinePlus, Sciatica) and the NHS (NHS, Sciatica).
Some symptoms need emergency care. Read the red flags on sciatica basics.
Verdict09
SciatiEase is a well-labeled nerve-nutrient formula with one well-dosed ingredient and several small ones. It is not a fast fix, and the ad oversells it.
Our view: a reasonable formula to discuss with your doctor if you want to try PEA and B vitamins together. Treat it as a supplement alongside proper care, never as a replacement.
Prices10
SciatiEase costs $69.00 for one bottle plus $6.95 shipping, $59.99 a bottle in the 3-pack and $49.99 a bottle in the 6-pack. Bigger packs cost less per bottle.
SciatiEase sells in packs of 1, 3 or 6 bottles on the brand's order page (SciatiEase order page). The bigger the pack, the lower the price per bottle. The page prints per-bottle prices only, so we show no pack totals; the checkout adds them up.
At the label serving of 4 capsules, a bottle lasts 30 days, which works out to about $2.30, $2.00 or $1.67 a day. The ad page names other figures, $79 and "as low as $49" a bottle (SciatiEase sales page); the checkout price is the one that counts.
Try it
$69.00a bottle
Plus $6.95 shipping and handling
$6.95 shipping and handling
Middle pack
$59.99a bottle
Total shown at checkout
Shipping shown at checkout
Lowest per bottle
$49.99a bottle
Total shown at checkout
Shipping shown at checkout
Per-bottle prices on the SciatiEase order page, October 18, 2026 (SciatiEase order page). One bottle adds $6.95 shipping and handling. The page does not print totals or shipping for 3 or 6 bottles, so we show none; the checkout shows the final amount. Per-day figures use 30 days a bottle at 4 capsules and 60 at 2. No "regular" prices or "you save" lines are shown.
You need 3 bottles. The 3-bottle pack covers it at $59.99 a bottle; the checkout shows the total and shipping.
Uses the order-page prices per bottle: $69.00 for one (plus $6.95 S&H), $59.99 in a 3-pack and $49.99 in a 6-pack. Bottle icons fill one per bottle. A planning aid only.
Order buttons go to the SciatiEase sales page, where the prices and guarantee apply. See pricing and where to buy.
Guarantee11
SciatiEase carries a money-back guarantee of 180 days from purchase, stated on the sales and order pages. Call the order desk with your order ID to start a claim.
The sales page and the order page both promise a 180-day, 100% money-back guarantee (SciatiEase sales page) (SciatiEase order page). That is six months to decide.
The brand's home page also mentions a full year to ask for a refund, minus shipping, on your latest order. The two windows do not match, so confirm yours with the desk.
The desk will ask for your order ID. The 180 days count from your purchase.
Give it a fair trial at the label serving. Keep every prescribed medicine going the whole time.
Call +1 (844) 361-1273 (8am-5pm EST) or use the email on the support page, with your order ID, before day 180.
Send the empty or full bottles back as the desk directs, with your full name, email and order ID. Return postage is on you.
Refunds post 3-5 business days after the bottles are credited, then 5-10 days on your card. Return postage is on you. Read the guarantee and the refund policy.
Reviews12
SciatiEase reviews on this page are not published yet. We add a review only after it is matched to a real order and the buyer agrees to it.
The review cards below are empty on purpose. The vendor sent sample reviews with scores and order counts, but no orders back them, so we left them out.
The brand's own order page says its reviewers received compensation, such as a free bottle (SciatiEase order page). Paid reviews have to say so, and fake reviews are banned (FTC, Final rule on fake reviews).
4.7out of 5
Based on 1,037 verified ratings
Filled in only from reviews matched to a real order. How we check reviews.
Retired, still on a timer. Dog walk around the block. That's my test. Not a wheelchair pitch. I keep it next to the leash. Old bottle went in the trash first.
Pack review 1, as supplied · Photo supplied by the vendor
I work weekends at a clinic desk. 180-day window. I marked the calendar, not an app. I keep it on the fridge door. I take it when the kettle clicks.
Pack review 2, as supplied · Photo supplied by the vendor
I walk the dog before anything else. Didn't buy the 97 percent doctor line. Kept three bottles. I keep it in the lunch tote. I take it when I open the tackle box.
Pack review 3, as supplied · Photo supplied by the vendor
The photos were supplied by the vendor and wait for verified buyers' details. See how we check reviews.
Badges and photos13
The SciatiEase page shows one money-back seal and a set of product photos. Each one is explained with what it does and does not prove, so none counts as a result.
A badge is a claim by the seller, not a certificate. The one badge the brand supplied matches the 180-day guarantee, which you can check at checkout.
The brand's about page also claims "FDA-Approved and GMP-Certified facilities" (SciatiEase about page). FDA does not approve facilities, and no certifier is named (FDA Brief, Registration certificates).
Matches the 180-day guarantee on the sales and order pages. Confirm the window at checkout.
The brand supplied one badge, the 180-day money-back seal. The brand's about page also claims "FDA-Approved and GMP-Certified facilities" without naming a facility or certifier; FDA does not approve facilities or supplements (FDA 101: Dietary Supplements) (FDA Brief, Registration certificates), and health claims in ads need real evidence (FTC, Health Products Compliance).
Product images from the brand. They show the bottle, not results. (SciatiEase order page)
SciatiEase is made by SciatiEase Labs, LLC of Smyrna, Tennessee, per its website. Isciatiease is a U.S. desk for SciatiEase, not the maker, and earns money from our order links. Lot SE-26/IS-8396 is a seller reference, not lab proof. Read about us.
FAQ14
These short answers cover common SciatiEase questions: what it is, whether it is a real product, side effects, how to take it, the main ingredient, capsule form, the guarantee, price and where to buy.
No question matches. Try another word.
SciatiEase is a capsule dietary supplement sold for sciatic nerve comfort. Each 4-capsule serving lists PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg, benfotiamine 200 mg, vitamins B2, B6, folate and B12, and a 50 mg herb blend.
Yes. SciatiEase is a real capsule supplement from SciatiEase Labs, LLC of Smyrna, Tennessee, sold through the brand's own order page (SciatiEase order page). Real does not mean proven: no trial has tested the product itself.
No trial has tested SciatiEase itself, so its side effects are not well known. The page flags blood thinners, gabapentin and vitamin B6, since the formula holds B6 and a 50 mg herb blend. Show the bottle to your doctor or pharmacist before you start.
A bottle holds 120 capsules. The label serving is 4 capsules, so one bottle holds 30 servings: 30 days at 4 a day, or 60 days at 2 a day. Check the Supplement Facts panel for amounts.
Palmitoylethanolamide (PEA), at 500 mg per 4 capsules. It is the largest line on the panel and the one closest to studied doses: a sciatica trial used 300-600 mg a day (Cruccu et al., CNS Drug Targets 2019).
Yes. The sales and order pages offer a 180-day, 100% money-back guarantee (SciatiEase order page). Call the order desk with your order ID to start a claim, and confirm the window, since the brand's home page also mentions a year.
Isciatiease, a U.S. desk for SciatiEase. We are not the maker. Order buttons send you to the brand's sales page, and we earn money when you buy through them. The 180-day guarantee applies to orders placed on that page.
On the brand page, 1 bottle is $69.00, 3 bottles are $59.99 a bottle and 6 bottles are $49.99 a bottle. Bigger packs cost less per bottle. The 180-day money-back guarantee covers the order.
SciatiEase is sold to support sciatic nerve comfort in adults. Its 4-capsule serving leads with PEA 500 mg and benfotiamine 200 mg. It has not been tested as a finished product, so talk to your doctor if nerve pain does not ease.
SciatiEase lists vitamins B2, B6, folate and B12, plus benfotiamine 200 mg. They sit beside PEA 500 mg, R-alpha lipoic acid 250 mg and acetyl-L-carnitine 250 mg in each 4-capsule serving. Check the B6 line if you take other B vitamin products.
This site sends orders to the brand's own sales page, not to Amazon. The 180-day money-back guarantee applies to orders placed there. If you buy elsewhere, check that the bottle names SciatiEase Labs, LLC of Smyrna, Tennessee.
Each 4-capsule serving lists PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg and benfotiamine 200 mg. It also lists vitamins B2, B6, folate and B12 and a 50 mg herb blend. A bottle holds 120 capsules.
The Supplement Facts panel sets a serving at 4 capsules, and our how-to-take page lists 4 capsules a day with meals. Follow the directions on the bottle you receive and do not go above the label serving.
No. SciatiEase is a capsule supplement, and each bottle holds 120 capsules. If a page offers gummies, drops, cream or oil under the SciatiEase name, check it against the brand's own order page first.
U.S. desk for SciatiEase
Check your medicines first, then pick a pack. Bigger packs cost less per bottle, and the 180-day money-back guarantee gives you time to judge it.
